Benzyl penicillinic acid sodium salt
Penicillin G Sodium
CAS: 69-57-8
Molecular Formula: C16H17N2NaO4S
Benzyl penicillinic acid sodium salt - Names and Identifiers
Benzyl penicillinic acid sodium salt - Physico-chemical Properties
| Molecular Formula | C16H17N2NaO4S |
| Molar Mass | 356.37 |
| Density | 1.41 |
| Melting Point | 209-212°C |
| Boling Point | 663.3°C at 760 mmHg |
| Specific Rotation(α) | D24.8 +301° (c = 2.0 in water) |
| Flash Point | 355°C |
| Water Solubility | 5-10 g/100 mL at 25 ºC |
| Solubility | Soluble in water, decomposition point is 215 ℃, easily soluble in water, soluble in ethanol, insoluble in fatty oil liquid paraffin. |
| Vapor Presure | 1.69E-18mmHg at 25°C |
| Appearance | White to off-white crystalline powder |
| Color | colorless or white |
| Merck | 14,7094 |
| BRN | 3834217 |
| PH | 5.5-7.5 (3% in H2O) |
| Storage Condition | Inert atmosphere,2-8°C |
| Stability | Stability Stable, but incompatible with a wide variety of materials, including acids, oxidizing agents, heavy metals, alcohols, glycerol, thiomersal, many surface-active agents, alkalies, peroxides |
| Refractive Index | 300 ° (C=2, H2O) |
| MDL | MFCD00069666 |
| Physical and Chemical Properties | Density 1.41 melting point 209-212°C water-soluble 5-10g/100 mL at 25°C |
| Use | For antibiotics, mainly used for Streptococcus, Pneumonia cocci, meningococcal infection |
Benzyl penicillinic acid sodium salt - Risk and Safety
| Risk Codes | 42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 2 |
| RTECS | XH9800000 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29411000 |
| Toxicity | LD50 oral in rat: 6916mg/kg |
Benzyl penicillinic acid sodium salt - Upstream Downstream Industry
| Raw Materials | Phenylacetic acid n-Butyl acetate Ammonium sulfate Ammonium sulfate Sodium sulfate Dextrose Anhydrate Benzylpenicillin potassium Sodium hydroxide Ethyl Alcohol Ethyl acetate 1-Butanol |
Benzyl penicillinic acid sodium salt - Reference
| Reference Show more | 1. Su mongru, Ma Peipei, Li Xinxin et al. Determination of Minimum inhibitory concentrations of 9 antimicrobial agents against Escherichia coli [J]. Advances in animal medicine 2020 041(003):52-56. 2. Chen Chengning Xibin. Screening and identification of a strain producing β-lactamase and preliminary study on its enzymatic properties [J]. Food and Fermentation Industries 2019 45:77-83. 3. Lei Nan, Feng, Liu, Tian, Huang, he, Yong, Li, Qiumei, Hong, Mei. Effect of tamoxifen on the expression of mTOR and survivin in human hepatoma HepG2 cells [J]. Cancer pharmacy 2015 5(03): -198. 4. Meng Zhiping, Lu Manqi, Su Wenqiang, etc. Preparation of berberine hydrochloride powder spray and its effect on Staphylococcus aureus Pneumonia [J]. Chinese herbal medicine, 2020, v.51;No.661(02):73-80. 5. Deng Wen, Yu Xueli, Peng Youzhi, etc. Effect of cooling rate on sperm quality during semen balance in sheep [J]. Journal of Animal Science and Veterinary Medicine, 2010, 37(004):109-112. 6. Mao with the year, Hu Jiahuan, Liu Yixiu. Inhibitory effect of Artemisia argyi extract on Staphylococcus aureus [J]. Modern food science and technology, 2018, 34(11):89-94. 7. Wu Yu, Rui bin, Ye Feng, et al. Effect of propofol down-regulating miR-93-5p expression on proliferation and invasion of breast cancer MDA-MB-231 cells [J]. Chinese pharmacist 2020 v.23(06):48-53. 8. Shi kuihao, Zhang Guangcai, Wu kangxiong, Wang Bin, Wan Min Ge, Li Min. Comparison of in vitro pharmacological activities of four flavonoid glycosides from Epimedium [J]. Journal of Shaanxi University of Science and Technology, 2021,39(02):56-61. 9. Zhang Liu-ming, Ma Jin-Liang, Feng Yunkui, Qin Chang-Jiang, Hu Huiru, tagq Sohail, Wang Yanhu, Li Yongjun. Effect of glycerol on the preservation of Hu sheep semen at room temperature [J]. Journal of Yangzhou University (Agriculture and Life Science Edition),2020,41(05):69-74. 10. Li, Lei, et al. "A TIMS-TOF mass spectrometry study of discacarides from in situ ESI derivation with 3-pyridinylboronate." Analyst 146.1 (2021): 75-84.doi: 10.1039/doan01677b 11. Chunxi Zhao, Yang Jiao, He Gao, Yaling Yang, Hong Li, N, S co-doped carbon dots for temperature probe and the detection of tetracycline based on the inner filter effect, Journal of Photochemistry and Photobiology A: Chemistry, Volume 367, 2018, Pages 137- 12. [IF=4.034] Shan Shan et al."Sensitive detection of Escherichia coli O157:H7 based on cascade signal amplification in ELISA."J Dairy Sci. 2016 Sep;99:7025 13. [IF=4.034] Jia Cheng et al."Antimicrobial resistance profiles of 5 common bovine mastitis pathogens in large Chinese dairy herds."J Dairy Sci. 2019 Mar;102:2416 14. [IF=2.932] Jihui Wang et al."Linoelaidic acid enhances adipogenic differentiation in adipose tissue-derived stromal cells through suppression of Wnt/β-catenin signaling pathway in vitro."Prostag Leukotr Ess. 2016 Jul;110:1 15. [IF=2.1] Lei Liu et al."Suppression of calcium‑sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy."Mol Med Rep. 2016 Jul;14(1):111-120 16. [IF=7.514] Zi-Tao Zhong et al."Quantitative analysis of various targets based on aptamer and functionalized Fe3O4@graphene oxide in dairy products using pregnancy test strip and smartphone."Food Chem. 2021 Aug;352:129330 17. [IF=4.098] Ai-Yue Hao et al."A smartphone-combined ratiometric fluorescence probe for specifically and visibly detecting cephalexin."Spectrochim Acta A. 2021 Mar;249:119310 18. [IF=6.543] Chen Weikai et al."Melatonin Improves the Resistance of Oxidative Stress-Induced Cellular Senescence in Osteoporotic Bone Marrow Mesenchymal Stem Cells."Oxid Med Cell Longev. 2022;2022:7420726 19. [IF=4.821] Weidao Yu et al."A turn-on fluorescent aptasensor for ampicillin detection based on gold nanoparticles and CdTe QDs."Microchem J. 2022 Aug;179:107454 |
Benzyl penicillinic acid sodium salt - Standard
Authoritative Data Verified Data
(2S,5R,6R)-3, 3-dimethyl-6-(2-phenylacetamido)-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid sodium salt. Calculated as dried product, including C16H17N2Na04 shall not be less than 96.0%.
Last Update：2024-01-02 23:10:35
Benzyl penicillinic acid sodium salt - Trait
Authoritative Data Verified Data
- This product is a white crystalline powder; Odorless or slightly specific odor; Hygroscopicity; Rapid failure when exposed to acid, alkali or oxidant, and easy failure when placed in aqueous solution at room temperature.
- This product is very soluble in water, soluble in ethanol, insoluble in fatty oil or liquid paraffin.
Last Update：2022-01-01 13:32:57
Benzyl penicillinic acid sodium salt - Introduction
Soluble in water, decomposition point is 215 ℃, easily soluble in water, soluble in ethanol, insoluble in fatty oil liquid paraffin. It is hygroscopic, and can make the β-lactam ring of penicillin open and fail in case of acid, alkali, oxidant, penicillinase, etc.
Last Update：2022-10-16 17:27:57
Benzyl penicillinic acid sodium salt - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 222).
- This product shows the reaction of sodium salt identification (1) (General rule 0301).
Last Update：2022-01-01 13:32:58
Benzyl penicillinic acid sodium salt - Exam
Authoritative Data Verified Data
crystallinity
take a small amount of this product, according to the law inspection (General 0981), should comply with the provisions.
pH
take this product, add water to make a solution containing 30mg per lml, according to the law (General 0631),pH value should be 5.0~7.5.
clarity and color of solution
take 5 parts of this product, each 0.3g, respectively, add water 0902 to dissolve, the solution should be clear and colorless; If it is turbid, compare with No. 1 turbidity standard solution (General rule first method), shall not be more concentrated; If the color is developed, it shall not be deeper in comparison with the yellow or yellow-green No. 1 Standard Colorimetric solution (General Principles 0901 first method).
absorbance
take this product, precision weighing, add water to dissolve and quantitatively dilute to make a solution containing about 0401 mg per lml, according to UV-visible spectrophotometry (general rule), measured at 280nm and 325nm wavelengths, the absorbance shall not be greater than 0.10; There is maximum absorption at 264nm wavelength, and the absorbance shall be 0.80~0.88.
Related substances
take an appropriate amount of this product, add water to dissolve and quantitatively dilute to make a solution containing about 4mg per lml as a test solution; Take 1.0 for precision measurement and put it in a 100ml measuring flask, dilute with water to the scale, as a control solution | Precision take the appropriate amount of control solution, quantitative dilution with water to make about l per 1 ml. Oug solution, as a sensitivity solution. Test according to high performance liquid chromatography (General 0512). With eighteen alkyl silane bonded silica gel as filler; Phosphate buffer (take potassium dihydrogen phosphate 10.6g, add water to 3.4, with phosphoric acid to adjust the pH value to)-methanol (72:14) as mobile phase A, the detection wavelength of acetonitrile was 225nm, the flow rate was 1.0ml per minute, and the column temperature was 34°C. Take the appropriate amount of penicillin system applicable reference substance, add water to dissolve and dilute to make A solution containing about 4mg per lml, take 20ul into the liquid chromatograph; First use mobile phase A- mobile phase B(86.5:13.5) after the third chromatographic peak of impurity E (see reference spectrum) is eluted, linear gradient elution shall be carried out immediately according to the following table, and the recorded chromatogram shall be consistent with the standard spectrum. The sensitivity solution 20ul is injected into the liquid chromatograph, and the signal-to-noise ratio of the peak height of the principal component chromatography should be greater than 10. 20ul of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatograms were recorded. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%). The peaks in the chromatogram of the test solution which are smaller than the main peak area of the sensitivity solution are ignored.
penicillin polymer
measured by size exclusion chromatography (General 0514).
chromatographic conditions and system suitability test
with dextran gel 010(40 ~ 120um) as the filler, the inner diameter of the glass column was 1.0~1.4, the column length was 30 ~ 40cm, and the mobile phase A was O at pH 7.0. lmol/L phosphate buffer [0.1 mol/L disodium hydrogen phosphate solution -0.1 mol/L sodium dihydrogen phosphate solution (61:39)], mobile phase B is water, flow rate is 1.5ml per minute, detection wavelength is 254nm, 2000 mg/ml Blue dextran 100 Solution 200 ~ u1, injection of human liquid chromatography, respectively, with mobile phase A, B for determination, record chromatogram. The number of theoretical plates is not less than 2000 calculated by the Blue dextran 400 peak, and the tailing factor should be less than 2.0. The ratio of the retention times of the Blue dextran 2000 peak in the two mobile phase systems should be between 0.93 and 1.07, the ratio of the retention time of the main peak of the control solution to the polymer peak in the test solution and the Blue dextran 2000 peak in the corresponding chromatography system should be between 0.93 and 1.07. Take about 0.4g of this product, put it in a 10ml measuring flask, add 2000 mg /ml Blue dextran solution to dissolve and dilute to the scale, shake. 100~200u1 was injected into the liquid chromatograph, and the measurement was performed with the mobile phase A, and the chromatogram was recorded. The ratio of the peak height of the polymer to the valley height between the monomer and the polymer should be greater than 2.0. In addition, the mobile phase B is used as the mobile phase, and the relative standard deviation of the peak area should not be more than 100 when the control solution is 200-5.0% u1 for 5 consecutive injections.
preparation of control solution
take an appropriate amount of penicillin reference substance, weigh it precisely, add water to dissolve and quantitatively dilute to make a solution containing about 0.1 mg per 1 ml.
assay
take about 0.4g of this product, weigh it accurately, put it in a 10ml measuring flask, add an appropriate amount of water to dissolve it, dilute it with water to the scale, and shake it well, immediately, 100-200ul was injected into the human liquid chromatograph, and the mobile phase A was used as the mobile phase for measurement, and the chromatogram was recorded. In addition, 100~200u1 of the control solution was injected into the human liquid chromatograph, and the mobile phase B was used as the mobile phase for measurement, and the chromatogram was recorded. According to the external standard method to calculate the peak area of penicillin, the amount of penicillin polymer should not exceed 0.08%.
loss on drying
take this product, dry at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
visible foreign body
take 5 parts of this product, each 2.4g, plus particle inspection water dissolution, inspection according to law (General 0904), should comply with the provisions. (For aseptic dispensing)
insoluble particles
Take 3 parts of this product, and make a 60mg solution per lml with water for particle inspection, and check it according to law (General rule 0903). In each lg sample, particles containing 10um and more than 10um shall not exceed 6000 particles, and particles containing 25um and more than 25um shall not exceed 600 particles. (For aseptic dispensing)
bacterial endotoxin
take this product, check according to law (General rule 1143), every 1000 penicillin units containing endotoxin in children should be less than 0.10EU. (For injection)
sterile
take this product, dissolve with appropriate solvent, add penicillinase inactivation or diluted with appropriate solvent, after membrane filtration treatment, inspection according to law (General rule 1101), should comply with the provisions. (For aseptic dispensing)
Last Update：2022-01-01 13:32:59
Benzyl penicillinic acid sodium salt - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with eighteen alkyl silane was used as the filler, and the mobile phase A- mobile phase B(70:30) was used as the mobile phase, and the detection wavelength was 225nm; take an appropriate amount of penicillin system applicable reference substance, add water to dissolve and dilute to make a solution containing about 1 mg per 1 ml, and inject 20ul into the liquid chromatograph. The chromatogram recorded should be consistent with the standard spectrum.
assay
take an appropriate amount of this product, accurately weigh it, add water to dissolve and quantitatively dilute it to make a solution containing about 1 mg per 1 ml, and use it as a test solution. Take 20ul of precision and inject it into human liquid chromatograph, record the chromatogram; Take the appropriate amount of penicillin reference substance, the same method for determination. The content of Cl6H17N2Na04S in the test product is calculated by the peak area according to the external standard method, and the result is multiplied by 1.0658.
Last Update：2022-01-01 13:33:00
Benzyl penicillinic acid sodium salt - Category
Authoritative Data Verified Data
B-lactam antibiotics, penicillins.
Last Update：2022-01-01 13:33:00
Benzyl penicillinic acid sodium salt - Storage
Authoritative Data Verified Data
sealed and stored in a cool, dark and dry place.
Last Update：2022-01-01 13:33:00
Benzyl penicillinic acid sodium salt - Penicillin sodium for injection
Authoritative Data Verified Data
This product is a sterile powder of penicillin sodium. Calculated as dried product, the content of C16H17N2Na04S shall not be less than 96.0%; Calculated as the average loading, the content of C16H17N2Na04S shall be 95.0% ~ 115.0% of the labeled amount.
trait
This product is a white crystalline powder.
identification
take this product, according to penicillin sodium under the identification test, showed the same results.
examination
- the clarity and color of the solution take 5 bottles of this product, and add water to prepare a solution containing 60mg per lml according to the indicated amount. The solution should be clear and colorless; If it is turbid, no one shall be more concentrated than the turbidity standard liquid No. 1 (General rule 0902 method 1), and no one shall be deeper than the yellow or yellow-green standard colorimetric liquid No. 2 (General rule 0901 method 1) in case of color development.
- the content under the item of difference in the amount of penicillin polymer taken was measured according to the method under the item of penicillin sodium. According to the external standard method to calculate the peak area of penicillin, the amount of penicillin polymer shall not exceed 0.10% of the labeled amount.
- weight loss on drying this product, drying at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
- insoluble particles this product is taken, and the labeled amount is added to the particle inspection water to make a solution containing 60mg per 1 ml, which is inspected according to law (General rule 0903), and the labeled amount is 1. The conversion below Og is that no more than 6000 particles of 10um or more and no more than 600 particles of 25um or more should be contained in every 1.0g sample; the labeled amount is more than 6000G (including 1.Og), and the particles containing 10um and more than 10um in each sample container shall not exceed 600 particles, and the particles containing 25um and more than 25um shall not exceed particles.
- the pH value, related substances, bacterial endotoxin and sterility shall be checked according to the method under the item of penicillin sodium, and shall be in accordance with the regulations.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
The contents under the item of loading amount difference were taken and measured according to the method under the item of penicillin sodium. Each 1 mg of C16H17N2Na04S is equivalent to 1670 penicillin units.
category
with penicillin sodium.
specification
Based on C16H17N2Na04S (l)0.12g (200,000 units)(2)0.24g (400,000 units) (3)0.48g (800,000 units) (4)0.6g(1 million units) (5)0.96g (1.6 million units) (6)2.4g(4 million units)
storage
sealed and stored in a cool, dark and dry place.
Last Update：2022-01-01 13:33:01
Benzyl penicillinic acid sodium salt - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| drug interaction | on drug interaction. The absorption of penicillin sodium can be reduced by the combination of penicillin sodium and bile amine. A possible mechanism is that penicillin is bound by cholangiography. The plasma level of penicillin sodium is reduced by 78%-79% and the area under the plasma concentration-time curve (AUC) is reduced by 75%-85% when combined with nordanmin. When combined with methotrexate, because of competing renal tubular secretion, the renal clearance of methotrexate can be reduced, increasing methotrexate toxicity, while penicillin potassium does not. |
| dosage | intramuscular injection: 800,000~2 million U Daily, 3~4 times: 2 million -1 0 U per day, 2-4 doses. The dosage of severe meningitis and endocarditis can reach 2 0 U/d. |
| pharmacological action and application | interferes with the synthesis of bacterial cell wall and plays a bactericidal role in the reproductive period of bacteria. It has antibacterial effect on G coccus and G bacillus (diphtheria, tetanus, Bacillus anthracis), spirochete, Clostridium, actinomycetes and some Bacteroides. This product is not acid-resistant and enzyme-resistant. It is used for various infections caused by sensitive bacteria and is ineffective against G-bacilli. |
| Use | penicillin has the advantages of strong antibacterial effect, high curative effect and low toxicity, so it is still widely used. Penicillin is an organic acid, can be combined with a variety of metals into a salt, commonly its sodium salt or potassium salt. Penicillin can be chemically cleaved to remove the acyl group to produce 6-APA (6-aminopenicillanic acid), which is an intermediate of various semi-synthetic penicillins. is an antibiotic drug, mainly used for Streptococcus, Pneumonia cocci, meningococcal infection, inhibition of bacterial cell wall synthesis. Antimicrobial Spectrum: Gram-positive bacteria. |
| production method | using a hybrid strain of Penicillium chrysogenum (Penicillium chryso-genum), produced by microbial fermentation. |
Last Update：2024-04-09 02:00:10
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View History
Benzyl penicillinic acid sodium salt
N-BOC-2-氨基-2-氰基乙酸乙酯
5-氟-3-吡啶硼酸
Ethyl2-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carBoxylate
3-Dimethylaminopropylamine
2-AMINO-1-METHYLBENZIMIDAZOLE
p-Iodoethylbenzene
2-丁基正辛醇
2,2,3-trihydroxyoctadecanoic acid
D,L-Azatryptophan Hydrate
N-BOC-2-氨基-2-氰基乙酸乙酯
5-氟-3-吡啶硼酸
Ethyl2-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carBoxylate
3-Dimethylaminopropylamine
2-AMINO-1-METHYLBENZIMIDAZOLE
p-Iodoethylbenzene
2-丁基正辛醇
2,2,3-trihydroxyoctadecanoic acid
D,L-Azatryptophan Hydrate
Raw Materials for Benzyl penicillinic acid sodium salt
Phenylacetic acid
n-Butyl acetate
Ammonium sulfate
Ammonium sulfate
Sodium sulfate
Sodium hydroxide
1-Butanol
n-Butyl acetate
Ammonium sulfate
Ammonium sulfate
Sodium sulfate
Sodium hydroxide
1-Butanol